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Saturday, April 20, 2019

Printable Organs


            Today, we are already at a turning point in our ability to 3D “bioprint” organ tissues, a process that involves depositing a “bio-ink” made of cells precisely in layers, resulting in a functional living human tissue for use in the lab. These tissues should be better predictors of drug function than animal models in many cases. In the long-term, this has the potential to pave the way to “printing” human organs, such as kidneys, livers and hearts. 


       
             Achieving such an outcome would be truly remarkable. Despite advances in medicine and increased awareness of organ donation, the gap between supply and demand of organs continues to widen. Without an accurate digital model of your target organ, bioprinters have nothing to guide them. This necessity gets more evident when attempting to grow a large solid, organ with its complicated architecture involving blood vessels, different cell types and geometrical quirks.

         Though printable organs won’t come easily, there is reason for optimism: i) Regenerative medicine isn’t brand new, ii) Costs are decreasing, Research is focused on the whole body, iii) 3D printed tissues and organs show promise in the lab. By 2020, our goal is to have the technology be broadly used by pharmaceutical companies, resulting in the identification of safer and better drug candidates and fewer failures in clinical trials.

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